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Los Alamos Science No. 18, 1989

AIDS Research

In the late 1980's, before it was known that all people are vulnerable to HIV/AIDS, various members of LANL's Theoretical Division began to research basic questions about the growth of the AIDS epidemic and the evolutionary origins of the deadly virus. They developed a risk-based model outlining the growth of the epidemic, who is at risk, and what intervention strategies would be most effective. To trace the evolution of the virus and the rate at which it was mutating, LANL scientists also established a DNA Sequence Database for HIV. This volume discusses these topics and also includes a tutorial, "AIDS Viruses of Animals and Man," which explains how retroviruses, known as lentiviruses, act as parasites of the immune system and discusses the prospects for an HIV vaccine. Since publication of the volume, research on the mutation of the HIV virus and the development of treatment strategies has continued at LANL (see article in 60th anniversary volume).

Table of ContentsPDF Size
Cover and Table of Contents

790 kB
Aids and a Risk-Based Model
Stirling A. Colgate, E. Ann Stanley, James M. Hyman, Clifford R. Quails, and Scott P. Layne
6271 kB
Genealogy and Diversification of the AIDS Virus
Gerald L. Myers, C. Randal Linder, and Kersti A. Maclnnes
2760 kB
AIDS Viruses of Animals and Man: Nonliving Parasites of the Immune System
Peter Nara of the National Cancer institute
6855 kB
The Kinetics of HIV Infectivity
Scott P. Layne, Micah Dembo, and John L. Spouge
2497 kB

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